FITC标记的BCL10结合蛋白和激活核转录因子抗体
产品名称： FITC标记的BCL10结合蛋白和激活核转录因子抗体
英文名称： Anti-CARD10/FITC
产品编号： HZ-7081R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CARD10/FITC Conjugated antibody
FITC标记的BCL10结合蛋白和激活核转录因子抗体
| 英文名称 | Anti-CARD10/FITC |
| 中文名称 | FITC标记的BCL10结合蛋白和激活核转录因子抗体 |
| 别 名 | Bcl10 binding protein and activator of NFKB; BIMP1; CAR10_HUMAN; CARD 10; CARD-containing MAGUK 3; CARD-containing MAGUK protein 3; CARD10; Carma 3; CARMA3; Caspase Recruitment Domain family member 10; Caspase recruitment domain-containing protein 10. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Monkey, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 116kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CARD10 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 ∑C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20∑C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ∑C. |
| 产品介绍 | background: Membrane-associated guanylate kinase (MAGUK) family members function as molecular scaffolds for the assembly of multiprotein complexes localizing to the plasma membrane. Several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product belong to the MAGUK family, including the caspase recruitment domain (CARD) protein family with the exception of CARD9. The CARD domain consists of 6 or 7 antiparallel alpha helices. CARD family members participate in apoptosis signaling through highly specific protein-protein homophilic interactions. CARD 10 (also designated CARD-containing MAGUK protein 3 or Carma 3) interacts with BCL-10 to activate NFⅹB. CARD10 is expressed in a variety of adult and fetal tissues, including heart, kidney and liver, and in multiple cancer cell lines. Function: Activates NF-kappa-B via BCL10 and IKK. Tissue Specificity: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney. Similarity: Contains 1 CARD domain. Database links: Entrez Gene: 29775 Human Entrez Gene: 105844 Mouse Omim: 607209 Human SwissProt: Q9BWT7 Human SwissProt: P58660 Mouse Unigene: 57973 Human Unigene: 17629 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
膜相关鸟苷酸激酶（MAGUK）家族成员作为分子支架用于组装定位于质膜的多蛋白复合物。与果蝇肿瘤抑制盘相关的几种哺乳动物蛋白（DLG）基因产物属于MAGUK家族，包括Caspase募集结构域（CARD）蛋白家族，除CARD9外。卡域由6或7个反平行的α螺旋组成。卡家族成员通过高度特异性蛋白质-蛋白质-嗜同性相互作用参与细胞凋亡信号传导。CARD 10（也指定含有MAGUC蛋白3或CARMA 3的卡）与BCL -10相互作用以激活NF-κB。CAD10在多种成人和胎儿组织中表达，包括心脏、肾脏和肝脏，以及在多个癌细胞系中。