FITC标记的ENTPD8蛋白抗体
产品名称： FITC标记的ENTPD8蛋白抗体
英文名称： Anti-ENTPD8/FITC
产品编号： HZ-14604R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ENTPD8/FITC Conjugated antibody
FITC标记的ENTPD8蛋白抗体
| 英文名称 | Anti-ENTPD8/FITC |
| 中文名称 | FITC标记的ENTPD8蛋白抗体 |
| 别 名 | E NTPDase 8; ENTP8_HUMAN; EC 3.6.1.5; ecto-ATP-diphosphohydrolase; Ectonucleoside triphosphate diphosphohydrolase 8; GLSR2492; iver ecto ATP diphosphohydrolase; NTPDase 8; nucleoside triphosphate diphosphohydrolase-8; UNQ2492. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul a |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ENTPD8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the ecto-nucleoside triphosphate diphosphohydrolase (eNTPDase) protein family are glycosylated enzymes that hydrolyze nucleoside 5’-triphosphates and 5’-diphosphates in extracellcular space. The enzymatic activities of eNTPDase are dependent on cations such as magnesium and calcium. Members of this protein family differ in their affinities for triphosphates versus diphosphates as substrate material. NTPDase8, also known as ENTPD8 (ectonucleoside triphosphate diphosphohydrolase 8) or E-NTPDase 8, is a 495 amino acid multi-pass membrane protein belonging to the GDA1/CD39 NTPase family. As a canalicular ectonucleoside NTPDase, NTPDase8 is involved in hepatic NTPDase activity and helps concentrate extracellular nucleotides. NTPDase8 binds calcium as a cofactor, becomes glycosylated following translation and exists as two alternatively spliced isoforms. Function: ENTPD8 is a canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. There are two different isoforms. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: N-glycosylated. Similarity: Belongs to the GDA1/CD39 NTPase family. Database links: Entrez Gene: 377841 Human SwissProt: Q5MY95 Human Unigene: 512562 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
外源核苷三磷酸二磷酸水解酶（eNTPDase）蛋白家族的成员是在细胞外空间水解核苷5’-三磷酸和5’-二磷酸的糖基化酶。EtPDP的酶活性依赖于镁和钙等阳离子。这种蛋白质家族的成员在三磷酸盐与二磷酸盐作为底物材料的亲和力上存在差异。NTPDase8，也称为ENTPD8（外核苷酸三磷酸二磷酸水解酶8）或E-NTPDase8，是属于GDA1/CD39 NTPase家族的495个氨基酸的多路膜蛋白。NTPDase8作为一种小管外核苷NTPDase，参与肝脏NTPDase的活性，有助于细胞外核苷酸的浓缩。NTPDASE8结合钙作为辅因子，在翻译后变成糖基化，并作为两个交替剪接的亚型存在。