FITC标记的硫氧还蛋白结合蛋白2抗体
产品名称： FITC标记的硫氧还蛋白结合蛋白2抗体
英文名称： Anti-TXNIP/FITC
产品编号： HZ-3897R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TXNIP/FITC Conjugated antibody
FITC标记的硫氧还蛋白结合蛋白2抗体
| 英文名称 | Anti-TXNIP/FITC |
| 中文名称 | FITC标记的硫氧还蛋白结合蛋白2抗体 |
| 别 名 | ;THIF; thioredoxin binding protein 2; thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; Vitamin D3 up-regulated protein 1; TXNIP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TXNIP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt). Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Subunit: Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4. Subcellular Location: Cytoplasm Post-translational modifications: Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation. Similarity: Belongs to the arrestin family. Database links: UniProtKB/Swiss-Prot: Q9H3M7.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 硫氧还蛋白结合蛋白-2 (TRX-binding protein-2，TBP-2)又称:维生素D3上调蛋白1(Vitamin D3 up-regulated protein 1，VDUP1)或称硫氧还蛋白相互作用蛋白(Thioredoxin-interacting protein，Txnip)。 TBP-2与硫氧还蛋白(thioredoxin，TRX)的活性部位结合，抑制其活性，除了参与多种氧化应激反应，还具有多种生物学功能。 有学者认为：TBP-2与肿瘤密切相关，有些肿瘤组织中，TBP-2表达降低或缺失。TBP-2表达增高时，细胞周期停滞，肿瘤细胞繁殖受到抑制。目前已成为肿瘤研究的重要靶点 |
TXNIP可通过抑制硫氧还蛋白活性或限制其生物利用度作为氧化应激介质。它与COPS5相互作用，并恢复COPS5诱导的CDKN1B稳定性的抑制，阻断CpKN1B介导的CKN1B从细胞核向细胞质的易位。它作为转录阻遏物，可能是作为转录因子和辅阻遏复合物之间的桥分子，过表达会诱导G0/G1细胞周期阻滞。这是自然杀伤细胞（来自SwissProt）成熟所必需的。