CDK5R1 (Human) Recombinant Protein (Q01)
产品名称： CDK5R1 (Human) Recombinant Protein (Q01)
英文名称： CDK5R1 (Human) Recombinant Protein (Q01)
产品编号： H00008851-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human CDK5R1 partial ORF ( AAH20580, 208 a.a. - 307 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- CRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
- Theoretical MW (kDa):
- 36.74
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 8851
- GeneBank Accession#:
- BC020580
- Protein Accession#:
- AAH20580
- Gene Name:
- CDK5R1
- Gene Alias:
- CDK5P35,CDK5R,MGC33831,NCK5A,p23,p25,p35,p35nck5a
- Gene Description:
- cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- Omim ID:
- 603460
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq
- Other Designations:
- CDK5 activator 1,TPKII regulatory subunit,cyclin-dependent kinase 5 activator 1,cyclin-dependent kinase 5, regulatory subunit 1,neuronal CDK5 activator,regulatory partner for CDK5 kinase,tau protein kinase II 23kDa subunit
- Gene Pathway