FITC标记的NK2转录样蛋白B抗体
产品名称: FITC标记的NK2转录样蛋白B抗体
英文名称: Anti-Nkx2.2/FITC
产品编号: HZ-11302R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Nkx2.2/FITC Conjugated antibody
FITC标记的NK2转录样蛋白B抗体
产品编号 | bs-11302R-FITC |
英文名称 | Anti-Nkx2.2/FITC |
中文名称 | FITC标记的NK2转录样蛋白B抗体 |
别 名 | Homeobox protein NK 2 homolog B; Homeobox protein NK-2 homolog B; Homeobox protein Nkx 2.2; Homeobox protein Nkx-2.2; NK 2 homolog B; NK2 homeobox 2; NK2 transcription factor like protein B; NK2 transcription factor related locus 2; NKX2 2; NKX2-2; NKX22; NKX22_HUMAN; Nkx2b; tinman. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 发育生物学 神经生物学 干细胞 转录调节因子 表观遗传学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 30kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Nkx2.2 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-2.1, Nkx-2.2 and Nkx-2.9. Specifically, the Nkx-2.2 protein is responsible for directing ventral neuronal patterning in response to graded Shh signaling. In the pancreas, Nkx-2.2 is expressed in a, b and pancreatic polypeptide (PP) cells, but not in d cells. Nkx-2.2 expression is required for differentiation of pancreatic b cells, which produce insulin. Homozygous null mutations of the Nkx-2.2 gene in mice lead to severe hyperglycemia and death shortly after birth, which suggests that Nkx-2.2 may be an important therapeutic target for pancreatic diseases, including diabetes and cancer. Function: May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Subunit: Interacts with OLIG2 (By similarity). Subcellular Location: Nucleus. Similarity: Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 4821 Human Entrez Gene: 18088 Mouse Entrez Gene: 366214 Rat Entrez Gene: 531695 Cow Omim: 604612 Human SwissProt: O95096 Human SwissProt: P42586 Mouse SwissProt: Q90481 Zebrafish Unigene: 516922 Human Unigene: 330639 Mouse Unigene: 32651 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NK-2家族的同源结构域蛋白是包括脑、心脏和胰腺在内的多种组织生长和发育的关键调节因子。在神经发育过程中,Sho-Hedgehog(Shh)是已知的控制细胞命运和有丝分裂,这与Shh剂量依赖性表达的几个基因,包括NKX-2.1,NKX-2.2和NKX-2.9。具体而言,NKX-2.2蛋白负责指导腹侧神经元图案化响应分级Shh信号。在胰腺中,NKX-2.2在A、B和胰腺多肽(PP)细胞中表达,而在D细胞中不表达。NKX-2.2的表达是胰岛B细胞分化所必需的,它产生胰岛素。小鼠NKX-2.2基因的纯合突变导致出生后不久的高血糖和死亡,提示NKX-2.2可能是胰腺疾病的重要治疗靶点,包括糖尿病和癌症。