FITC标记的叉头蛋白I1抗体
产品名称： FITC标记的叉头蛋白I1抗体
英文名称： Anti-FOXI1/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FOXI1/FITC Conjugated antibody
FITC标记的叉头蛋白I1抗体
| 英文名称 | Anti-FOXI1/FITC |
| 中文名称 | FITC标记的叉头蛋白I1抗体 |
| 别 名 | FKH10; FKHL10; Forkhead (Drosophila) like 10; Forkhead box I1; Forkhead box protein I1; Forkhead like 10; Forkhead related activator 6; Forkhead related transcription factor 6; Forkhead-related protein FKHL10; FREAC 6; FREAC6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH 3; HFH3; HNF 3/fork head homolog 3; HNF-3 fork-head homolog 3; Human HNF-3 fork-head homolog-3 HFH-3 mRNA complete cds; MGC34197; FOXI1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FOXI1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FOXI1 is a member of the FOX family of transcription factors. The FOX family is a large group of proteins (consisting of at least 43 members) that share a common DNA binding domain termed winged-helix or forkhead domain. FOX transcription factors play important roles in development, differentiation, aging and hormone responsiveness. Localizing to the nucleus, FOXI1 functions as a transcription factor. Mice with mutated forms of FOXI1 show defects in ear development, implying that FOXI1 plays a significant role in the developmental pathway of ears and, in particular, the cochlea and vestibulum. FOXI1 is an upstream transcription regulator of Pendrin (a protein associated with deafness), suggesting a role for FOXI1 in the pathogenesis of Pendred syndrome (PS), a condition of nonsyndromic hearing loss and enlarged vestibular aqueduct (EVA). Function: FOXI1 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. Subcellular Location: Nuclear. Tissue Specificity: Expressed in kidney. Similarity: Contains 1 fork-head DNA-binding domain. Database links: Entrez Gene: 2299 Human Entrez Gene: 14233 Mouse Entrez Gene: 287185 Rat Omim: 601093 Human SwissProt: Q12951 Human SwissProt: Q922I5 Mouse Unigene: 87236 Human Unigene: 32926 Mouse Unigene: 32116 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FoXI1是狐转录因子家族的成员。FOX家族是一大群蛋白质（由至少43个成员组成），它们共享一个共同的DNA结合结构域，称为翼螺旋结构域或叉头结构域。狐转录因子在发育、分化、衰老和应答中起着重要的作用。FXI1定位于细胞核，起转录因子的作用。具有突变形式的FOXI1小鼠在耳朵发育中表现出缺陷，这意味着FOXI1在耳朵的发育途径，特别是耳蜗和前庭中发挥着重要作用。FOXI1是Pendrin（一种与耳聋相关的蛋白）的上游转录调节因子，提示FOXI1在Pendred综合征（PS）、非综合征性听力损失和前庭水管扩大（EVA）的发病机制中起作用。