TP53 (phospho T55) polyclonal antibody-抗体-抗体-生物在线

产品名称： TP53 (phospho T55) polyclonal antibody

英文名称： TP53 (phospho T55) polyclonal antibody

产品编号： PAB1644

产品价格： null

产品产地：台湾

品牌商标： Abnova

更新时间： null

使用范围：

亚诺法生技股份有限公司（Abnova)

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Immunogen:
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T55 of human TP53.

Storage Instruction:
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Recommend Usage:
ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.

Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

1.
Guilt by association? p53 and the development of aneuploidy in cancer.
Duensing A, Duensing S.Biochem Biophys Res Commun. 2005 Jun 10;331(3):694-700.

2.
p53-A pro-apoptotic signal transducer involved in AIDS.
Castedo M, Perfettini JL, Piacentini M, Kroemer G.Biochem Biophys Res Commun. 2005 Jun 10;331(3):701-6.

3.
The multiple roles of p53 in the pathogenesis of HIV associated dementia.
Garden GA, Morrison RS.Biochem Biophys Res Commun. 2005 Jun 10;331(3):799-809.

Dot Blot (Peptide)
Dot blot analysis of TP53 (phospho T55) polyclonal antibody (Cat # PAB1644) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL.

Gene Summary:
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq

Other Designations:
p53 antigen,p53 transformation suppressor,p53 tumor suppressor,phosphoprotein p53,transformation-related protein 53