FITC标记的补体因子B抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的补体因子B抗体

FITC标记的补体因子B抗体

商家询价

产品名称： FITC标记的补体因子B抗体

英文名称： Anti-Factor B/FITC

产品编号： HZ-6949R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： IF=1:50-200

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 Rabbit Anti-Factor B/FITC Conjugated antibody

FITC标记的补体因子B抗体

 

产品编号 bs-6949R-FITC
英文名称 Anti-Factor B/FITC
中文名称 FITC标记的补体因子B抗体
别    名 AHUS4; B factor properdin; Factor B ; BF; BFD; C3 proaccelerator; C3 proactivator; C3/C5 convertase; CFAB; CFAB_HUMAN; CFB; Complement Factor B; Complement factor B Bb fragment; FB; FBI12; GBG; Glycine rich beta glycoprotein; Glycine-rich beta glycoprotein; H2 Bf; H2BF; PBF2; Properdin factor B,  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55/81kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Complement factor-B Bb fragment
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The complement component proteins, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. Complement Factor B, also designated Properdin Factor B or PBF2, is part of the alternate pathway of the complement system and is cleaved by Factor D into two fragments: Ba and Bb. Bb combines with complement Factor 3b to produce the C3 or C5 convertase and plays a role in the differentiation and proliferation of preactivated B lymphocytes, lysis of erythrocytes, stimulation of lymphocyte blastogenesis and rapid spreading of peripheral blood monocytes. Ba is important in inhibiting the proliferation of preactivated B lymphocytes. Adipsin, also designated complement Factor D, is a serine protease that cleaves complement Factor B and may be involved in obesity. Factor H controls the function of the alternative complement pathway. FHR-1 (complement Factor H related protein 1) may play a role in lipid metabolism.

Function:
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Subunit:
Monomer.

Subcellular Location:
Secreted.

DISEASE:
Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:612924]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 3 Sushi (CCP/SCR) domains.
Contains 1 VWFA domain.

Database links:
UniProtKB/Swiss-Prot: P00751.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
   

补体成分蛋白C3、C4和C5是补体激活过程中释放的有效的过敏毒素。这些蛋白质与它们各自的G蛋白偶联受体、C3AR、C1R和C5AR的结合，诱导促炎性事件，如细胞脱颗粒、平滑肌收缩、花生四烯酸代谢、细胞因子释放、白细胞活化和细胞趋化。补体因子B，也被命名为Properdin Factor B或PBF2，是补体系统的替代途径的一部分，并被因子D切割成两个片段：巴和BB。BB结合补体因子3B产生C3或C5转化酶，并在预激活B淋巴细胞的分化和增殖、红细胞裂解、刺激淋巴细胞的发生和外周血单核细胞的快速扩散中起作用。BA在抑制预激活B淋巴细胞的增殖中起重要作用。Adipsin，也被指定为补体因子D，是一种丝氨酸蛋白酶，裂解补体因子B，可能参与肥胖。H因子控制补体途径的功能。FR-1（补体因子H相关蛋白1）可能在脂质代谢中发挥作用。