RFWD3 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
RFWD3 抗体

RFWD3 抗体

商家询价

产品名称： RFWD3 抗体

英文名称： RFWD3 Antibody

产品编号： XY19893-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 RFWD3 抗体Applications

Tested Applications: ELISA, WB, IHC, IF
Specificity Reaction: Human, mouse, rat; Other species are not tested.Please decide the specificity by homology
Positive WB detected in Mouse lung tissue
Positive IHC detected in Human testis
Positive IF detected in Hela
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:20-1:200
 RFWD3 抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Prev12NextView more validation data
  • 19893-1-AP;mouse lung tissuemouse lung tissue were subjected to SDS PAGE followed by western blot with 19893-1-AP(RFWD3 antibody) at dilution of 1:1000
  • 19893-1-AP;human testisImmunohistochemical of paraffin-embedded human testis using 19893-1-AP(RFWD3 antibody) at dilution of 1:400 (under 10x lens)
  • 19893-1-AP;human testisImmunohistochemical of paraffin-embedded human testis using 19893-1-AP(RFWD3 antibody) at dilution of 1:400 (under 40x lens)
  • 19893-1-AP;HelaImmunofluorescent analysis of Hela cells, using RFWD3 antibody 19893-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Product Information
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information RFWD3 抗体
Immunogen: RFWD3 fusion protein ag13728 Full Name: Ring finger and WD repeat domain 3
Caculated Molecular
Weight:		 774aa,85 kDa Observed Molecular 
Weight:		 85kd
GenbankNo BC002574 GeneID: 55159
Symbol RFWD3 Synonyms RFWD3, RNF201, RING finger protein 201, FLJ10520
Background RFWD3 抗体

RFWD3, also named as RNF201, is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.(PMID: 20173098 ) From BLAST result, this antibody is specific to RFWD3. 45kd and 55kd maybe splicesome of RFWD3. RFWD3 抗体

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