MYC (phospho T358) Peptide
产品名称： MYC (phospho T358) Peptide
英文名称： MYC (phospho T358) Peptide
产品编号： P1523
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MYC.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T358 of human MYC.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Level of MYC overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the MYC locus.
Wilda M, Busch K, Klose I, Keller T, Woessmann W, Kreuder J, Harbott J, Borkhardt A.Genes Chromosomes Cancer. 2004 Oct;41(2):178-82.
- 2.
- Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells.
Dominguez-Caceres MA, Garcia-Martinez JM, Calcabrini A, Gonzalez L, Porque PG, Leon J, Martin-Perez J.Oncogene. 2004 Sep 23;23(44):7378-90.
- 3.
- p19ARF directly and differentially controls the functions of c-Myc independently of p53.
Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR.Nature. 2004 Oct 7;431(7009):712-7. Epub 2004 Sep 8.
- Applications
- Entrez GeneID:
- 4609
- Protein Accession#:
- NP_002458;P01106
- Gene Name:
- MYC
- Gene Alias:
- bHLHe39,c-Myc
- Gene Description:
- v-myc myelocytomatosis viral oncogene homolog (avian)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
- Other Designations:
- avian myelocytomatosis viral oncogene homolog,myc proto-oncogene protein,v-myc avian myelocytomatosis viral oncogene homolog
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