FITC标记的AU5 tag标签抗体
产品名称： FITC标记的AU5 tag标签抗体
英文名称： Anti-AU5 tag/FITC
产品编号： HZ-2113R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200
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Rabbit Anti-AU5 tag/FITC Conjugated antibody
FITC标记的AU5 tag标签抗体
| 英文名称 | Anti-AU5 tag/FITC |
| 中文名称 | FITC标记的AU5 tag标签抗体 |
| 别 名 | AU5 epitope tag; TDFYLK epitope tag; TDFYLK tag. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 标签抗体 |
| 研究领域 | 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | fusion protein,tagged T7 tag |
| 产品应用 | ICC=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated to AU5 tag |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptors-induced apoptosis remains controvertial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
核心蛋白包体病毒RNA形成病毒核衣壳，并促进病毒粒子出芽。通过与HCV ILE和40S核糖体亚基相互作用调节病毒翻译起始。也调节许多宿主细胞功能，如信号转导途径和细胞凋亡。通过阻断干扰素α/β（IFN-α/β）和IFN-γ信号通路和诱导人STAT1降解来阻止细胞抗病毒状态的建立。在病毒介导的细胞转化中发挥重要作用，导致肝细胞癌。与STAT3相互作用，并激活STAT3导致细胞转化。可能抑制p53的启动子，并在细胞质中分离CREB3和SP110亚型3/SP1B。抑制细胞周期负调控因子CDKN1A，从而中断正常细胞周期调控的重要检查点。靶向转录因子参与炎症反应和免疫应答的调节：抑制NK-κB活化，激活AP-1。介导TNF-型受体TNFRSF1A和LTBR介导的凋亡通路，虽然其对死亡受体诱导的细胞凋亡的影响仍然是可控的。增强TRAIL介导的细胞凋亡，提示它可能在介导的细胞凋亡中发挥作用，提示它可能在免疫介导的肝细胞损伤中发挥作用。分泌的核心蛋白能够在T细胞表面结合C1qR1，从而导致T淋巴细胞增殖的下调。可激活人MYC、RUS肉瘤病毒LTR和SV40启动子。可抑制人Fos和HIV-1 LTR活性。可能通过与参与脂质积累和储存的肝细胞蛋白相互作用而改变脂质代谢。