FITC标记的无精症缺失相关蛋白1抗体
产品名称： FITC标记的无精症缺失相关蛋白1抗体
英文名称： Anti-DAZAP1/FITC
产品编号： HZ-14200R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DAZAP1/FITC Conjugated antibody
FITC标记的无精症缺失相关蛋白1抗体
| 英文名称 | Anti-DAZAP1/FITC |
| 中文名称 | FITC标记的无精症缺失相关蛋白1抗体 |
| 别 名 | DAZ associated protein 1; DAZ-associated protein 1; Dazap1; DAZP1_HUMAN; Deleted in azoospermia associated protein 1; Deleted in azoospermia-associated protein 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DAZAP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] Function: RNA-binding protein, which may be required during spermatogenesis. Subcellular Location: Cytoplasm. Nucleus. Predominantly cytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm. Tissue Specificity: Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 2 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 26528 Human Entrez Gene: 427266 Chicken Entrez Gene: 614783 Cow Entrez Gene: 100683271 Dog Entrez Gene: 70248 Mouse Entrez Gene: 100433715 Orangutan Entrez Gene: 100625005 Pig Entrez Gene: 362836 Rat Entrez Gene: 707132 Rhesus monkey Entrez Gene: 398218 Xenopus laevis Entrez Gene: 448406 Xenopus tropicalis Omim: 607430 Human SwissProt: Q96EP5 Human SwissProt: Q9JII5 Mouse SwissProt: Q98SJ2 Xenopus laevis Unigene: 222510 Human Unigene: 148693 Mouse Unigene: 16769 Rat Unigene: 1666 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在哺乳动物中，Y染色体直接影响睾丸的发育，在精子发生过程中起着重要作用。高比例的不育男性有缺失到Y染色体区域的缺失。DAZ（无精子症中缺失）基因簇定位于Y染色体的AZFc区域，在许多无精子症和严重少精子症患者中缺失。认为DAZ基因簇是祖先常染色体基因DAZL的转位、扩增和剪枝产生的，也参与生殖细胞的发育和配子体的发生。该基因编码具有两个RNP基序的RNA结合蛋白，最初通过与不育因子DAZ和DAZL的相互作用来鉴定。两个异构体由该基因的转录变体编码。[ RefSeq，JUL 2008 ]