UBQLN2 polyclonal antibody
产品名称： UBQLN2 polyclonal antibody
英文名称： UBQLN2 polyclonal antibody
产品编号： PAB1700
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of UBQLN2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human UBQLN2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
Walters KJ, Kleijnen MF, Goh AM, Wagner G, Howley PM.Biochemistry. 2002 Feb 12;41(6):1767-77.
- 2.
- The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.
Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM.Mol Cell. 2000 Aug;6(2):409-19.
- 3.
- Selection system for genes encoding nuclear-targeted proteins.
Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M.Nat Biotechnol. 1998 Dec;16(13):1338-42.
- Applications
- Western Blot (Cell lysate)
- The UBQLN2 polyclonal antibody (Cat # PAB1700) is used in Western blot to detect UBQLN2 in HeLa cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with UBQLN2 polyclonal antibody (Cat # PAB1700) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with UBQLN2 polyclonal antibody (Cat # PAB1700) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 29978
- Protein Accession#:
- Q9UHD9
- Gene Name:
- UBQLN2
- Gene Alias:
- CHAP1,CHAP1/DSK2,Dsk2,HRIHFB2157,LIC-2,N4BP4,PLIC-2,PLIC2,RIHFB2157
- Gene Description:
- ubiquilin 2
- Omim ID:
- 300264
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq
- Other Designations:
- Nedd4 binding protein 4,bA431N15.1 (ubiquilin 2)