AGTRAP,血管紧张素Ⅱ受体相关蛋白抗体

产品编号HZ-7642R
英文名称AGTRAP
中文名称血管紧张素Ⅱ受体相关蛋白抗体
别 名Angiotensin Ⅱ receptor associated protein; Angiotensin Ⅱ type I receptor associated protein; ATI receptor associated protein; ATRAP; MGC29646; Type 1 angiotensin Ⅱ receptor associated protein; ATRAP_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 信号转导 G蛋白偶联受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep,
AGTRAP,血管紧张素Ⅱ受体相关蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量17kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AGTRAP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AGTRAP,血管紧张素Ⅱ受体相关蛋白抗体PubMedPubMed
产品介绍background:
AGTRAP (Angiotensin II receptor-associated protein) interacts with the angiotensin II type 1 receptor and negatively regulates type 1 angiotensin II receptor-mediated signaling, by regulating receptor internalisation as well as mechanisms of receptor desensitization such as phosphorylation.

Function:
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Subunit:
Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Tissue Specificity:
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.

Gene ID:
57085

Database links:
Entrez Gene: 57085 Human
Omim: 608729 Human
SwissProt: Q6RW13 Human
Unigene: 464438 Human

AGTRAP,血管紧张素Ⅱ受体相关蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片