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上海信裕生物科技有限公司
DSG2抗体

DSG2抗体

商家询价

产品名称： DSG2抗体

英文名称： DSG2Antibody

产品编号： XY 21880-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 DSG2抗体

Applications
In-house applications ELISA, WB, IF, IP     Application not tested? Please see our Guarantee.
Published applications IF Publications 1 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 21880-1-AP;HepG2 cellHepG2 cells were subjected to SDS PAGE followed by western blot with 21880-1-AP(DSG2 antibody) at dilution of 1:1000
  • 21880-1-AP;HepG2 cellsIP Result of anti-DSG2 (IP:21880-1-AP, 4ug; Detection:21880-1-AP 1:1000) with HepG2 cells lysate 3600ug.
  • 21880-1-AP;A431 cellsImmunofluorescent analysis of A431 cells using 21880-1-AP( DSG2 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in HepG2 cells, A431 cells, A549 cells, HEK-293 cells, HeLa cells
Positive IP detected in HepG2 cells
Positive IF detected in A431 cells
Recommended dilution WB : 1:1000-1:10000
IP : 1:500-1:5000
IF : 1:10-1:100
 DSG2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information DSG2抗体
Immunogen DSG2 fusion protein ag16393 Full name Desmoglein 2
Calculated molecular
weight		 1118aa,122 kDa Observed molecular 
weight		 145-150 kDa
GenBank accession 
number		 BC099655 Gene ID (NCBI) 1829
Gene symbol DSG2 Synonyms ARVC10, ARVD10, Cadherin family member 5, CDHF5, desmoglein 2, DSG2, HDGC
Background
 DSG2抗体

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG2 is a single-pass transmembrane glycoprotein that is widely expressed in epithelial and non-epithelial tissues, such as the intestine, epidermis, testis, and heart (PMID:21715983). Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10), and genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB).

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