Murine & Rat Growth Factors & Cytokines
Recombinant Murine Neuropoietin





 





		Synonyms :
NPO, NP



		Description :
Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway.  Recombinant murine Neuropoietin is a 19.8 kDa protein containing 183 amino acid residues.



		Catalog #:
250-25B



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.5-0.8 μg/ml.



                AA Sequence :
MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSAPELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV GDDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEEDTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YSA 



		PubMed Link :
Neuropoietin+AND+mouse


Country of Origin :
USA
















        Size A
5μg
$80 
 


 



        Size B
25μg
$195 
 


 



        Size C
1mg
$3900 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.